Impaired glucose tolerance in sleep disorders.

Impaired glucose tolerance in sleep disorders.

Blog Article

BackgroundRecent epidemiological and experimental data suggest a negative influence of shortened or disturbed night sleep on glucose tolerance.Due to the high prevalence of sleep disorders this might be a major health issue.However, no comparative studies of carbohydrate metabolism have been conducted in clinical sleep disorders.Methodology/principal findingsWe performed oral glucose tolerance tests (OGTT) and assessed additional parameters of carbohydrate metabolism in patients suffering from obstructive sleep apnea syndrome (OSAS, N = 25), restless legs syndrome (RLS, N = 18) usc trojans snapback hat or primary insomnia (N = 21), and in healthy controls (N = 33).

Compared to controls, increased rates of impaired glucose tolerance were found in OSAS (OR: 4.9) and RLS (OR: 4.7) patients, but not in primary insomnia patients (OR: 1.6).

In addition, HbA1c values were significantly increased in the same two patient groups.Significant positive correlations were found between 2-h plasma glucose values read more measured during the OGTT and the apnea-arousal-index in OSAS (r = 0.56; pConclusions/significanceOur findings suggest that some, but not all sleep disorders considerably compromise glucose metabolism.Repeated arousals during sleep might be a pivotal causative factor deserving further experimental investigations to reveal potential novel targets for the prevention of metabolic diseases.